Global and technological uncertainty is being weaponized by adversaries. Digital Transformation, Global Supply Chain issues, Mandated Lockdowns, and State Sponsored attacks are creating windows of opportunities for adversaries to exploit. We will discuss evolving attack trends and how defenders can employ core security pillars to mount a rigorous defense. Rigid defenses are obsolete and easily breached. Building an Automated and Malleable network will be the foundation of secure infrastructure over the next decade.